Toll-like receptors in the induction of the innate immune response
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- 17 August 2000
- journal article
- review article
- Published by Springer Nature in Nature
- Vol. 406 (6797) , 782-787
- https://doi.org/10.1038/35021228
Abstract
The innate immune response is the first line of defence against infectious disease. The principal challenge for the host is to detect the pathogen and mount a rapid defensive response. A group of proteins that comprise the Toll or Toll-like family of receptors perform this role in vertebrate and invertebrate organisms. This reflects a remarkable conservation of function and it is therefore not surprising that studies of the mechanism by which they act has revealed new and important insights into host defence.Keywords
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