Uptake of Methoxyflurane in Man at Constant Alveolar and at Constant Inspired Concentration

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Abstract
Methoxyflurane uptake in man was determined both at constant inspired concentration (0.75%) and at constant alveolar concentration (0.3%). Uptake at constant inspired concentration was relatively constant falling from an initial value of 40 ml/minute to a final value of 27 ml/minute after 100 minutes. Conversely, uptake at constant alveolar concentration began at a still higher level but rapidly fell below uptake at constant inspired concentration. Initially, uptake was 65 ml/minute. This fell to 30 ml at 20 minutes and 19 ml at 100 minutes. Despite the apparent smallness of these figures, they indicate removal of a large proportion of inspired anesthetic. In fact so much is removed during induction that it is physically difficult to produce inspired concentrations sufficient to attain or maintain anesthesia. It is particularly difficult to produce adequate concentrations with out-of circuit as opposed to in-circuit vaporizers.

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