NUCLEAR SHAPE VARIATIONS IN THE FASCICULAR ZONE OF THE RAT ADRENAL GLAND

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Abstract
Variations in nuclear volume and shape from one to 24 hours after exogenous corticotrophin (ACTH) administration have been studied in the fascicular zone of the rat adrenal gland. It appeared that ACTH gave rise to a transient rounding of the normally ovoid nucleus. The change in nuclear eccentricity was maximal at 6 hours and returned to normal within 9 hours. This variation in shape was concomitant with the initial stage of a more prolonged increase in nuclear volume as well as with a more transient elevation of the free plasma and adrenal tissue corticosteroid levels. Nuclear shape variations presumably constitute a morphological indication of increased cellular activity. It is pointed out that karyometric determination of nuclear shape variations might serve as a supplementary parameter in studies of adrenocortical function.

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