Effect of β‐Bungarotoxin on the Release of Endogenous Amino Acids from the Sensorimotor Cortex
- 1 July 1981
- journal article
- research article
- Published by Wiley in Journal of Neurochemistry
- Vol. 37 (1) , 251-254
- https://doi.org/10.1111/j.1471-4159.1981.tb05317.x
Abstract
.beta.-Bungarotoxin, a snake neurotoxin purified from the venom of Bungarus multicinctus, caused a significant increase in the in vivo release of glutamate from the superfused sensorimotor cortex of awake animals [rats]. A smaller effect on GABA release was observed, but no change was detected in the release of 6 other amino acids measured. The effects on glutamate and GABA release were entirely blocked by tetrodotoxin (1 .mu.M) and were reversible when the cortical tissue was washed with saline.Keywords
This publication has 13 references indexed in Scilit:
- The Effects of Scorpion Venom Toxin on the Release of Amino Acid Neurotransmitters from Cerebral Cortex In Vivo and In VitroJournal of Neurochemistry, 1980
- The action of γ-vinyl-GABA and γ-acetylenic-GABA on the resting and stimulated release of GABA in vivoBrain Research, 1980
- Actions of β‐Bungarotoxin on Amino Acid Transmitter ReleaseJournal of Neurochemistry, 1980
- Peripheral sensory stimulation and the release of transmitter amino acids in vivo from specific regions of cerebral cortexBrain Research, 1979
- Beta-Bungarotoxin. Separation of two discrete proteins with different synaptic actionsBiochemical Journal, 1978
- Effects of β-Bungarotoxin and Tityustoxin on Uptake and Release of NeurotransmittersBiochemical Society Transactions, 1978
- Mechanism of action of beta-bungarotoxin on synaptosomal preparations.Proceedings of the National Academy of Sciences, 1976
- The mechanism of β‐bungarotoxin action. I. Modification of transmitter release at the neuromuscular junctionJournal of Neurobiology, 1976
- A method for the continuous, long term superfusion of the cerebral cortex of unanaesthetized, unrestrained ratsJournal of Physics E: Scientific Instruments, 1974
- Release of amino acids from the chronically-superfused mammalian cerebral cortexJournal of Neurochemistry, 1974