(Na+ + K+) ATPase has one functioning phosphorylation site per α subunit
- 1 March 1981
- journal article
- research article
- Published by Springer Nature in Nature
- Vol. 290 (5804) , 338-339
- https://doi.org/10.1038/290338a0
Abstract
(Na+ + K+)ATPase contains 2 different subunits, a catalytic subunit (.alpha.) and a subunit with uncertain function (.beta.). The enzyme binds ATP, ouabain and vanadate, and can be phosphorylated by ATP as well as by inorganic phosphate. The enzyme apparently operates by means of a half-of-the-sites mechanism, whereby only 1 of the 2 .alpha. subunits can be phoshorylated at a time. Evidence is presented that every .alpha. subunit can be phosphorylated simultaneously, which rules out the operation of such a mechanism.This publication has 15 references indexed in Scilit:
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