The Effect of Isocaloric Substitution of Alcohol for Dietary Carbohydrate upon the Excretion of B Vitamins in Man

Abstract
The isocaloric replacement of carbohydrate (sugar and cornstarch) by ethyl alcohol in an adequate diet resulted in an increased excretion of thiamine and N1-methylnicotinamide in 2 human subjects. No significant changes were found in the excretion of creatinine, nitrogen, tryptophane, pantothenic acid and pteroylglutamic acid. These data may suggest that the substitution of alcohol for carbohydrate has a thiamine and nicotinic acid sparing action. The excretion of 4-pyridoxic acid on the carbohydrate diet was increased to unexplainably high levels.

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