Immunocytochemical localization of protein kinase C in resting and activated human neutrophils
- 14 September 1987
- journal article
- Published by Wiley in FEBS Letters
- Vol. 221 (2) , 365-369
- https://doi.org/10.1016/0014-5793(87)80957-2
Abstract
An immunocytochemical method was used to determine possible changes in the subcellular distribution of protein kinase C (PKC) in human neutrophils in response to opsonized latex beads and zymosan. While in resting cells most of the PKC immunoreactivity was localized in the cytoplasm, a redistribution of PKC to the plasma and phagosomal membranes was observed in cells treated with latex beads or zymosan for 5–20 min, suggesting a participation of PKC in endocytosisKeywords
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