[3 + 2] Coupling of Quinone Monoacetals by Combined Acid–Hydrogen Bond Donor
- 15 August 2011
- journal article
- research article
- Published by American Chemical Society (ACS) in Organic Letters
- Vol. 13 (18) , 4814-4817
- https://doi.org/10.1021/ol201886r
Abstract
The expeditious and efficient [3 + 2] coupling approach of quinone monoacetals 1 with alkene nucleophiles 2 by the action of an activated Bronsted acid in the presence of a hydrogen bond donor perfluorinated alcohol has been achieved. With the optimized combined acid, the reaction could proceed under mild conditions by only mixing the two reactants to afford the cycloadducts 3 in a short time (within 10 min) with good to quantitative yields.This publication has 43 references indexed in Scilit:
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