Studies and Comparison of Urinary Pteridine Patterns in Dogs and Cats and their Alteration in Various Neoplasias and Virus Infections

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Abstract
Summary Urinary excretion levels of five pteridines in healthy cats and dogs and in 14 groups of animals with tumours or virus infections were determined by HPLC after partial purification by ion exchange chromatography. Healthy cats and dogs produce species specific differences. In contrary to cats 6-hydroxymethylpterin was not detectable in dogs. Whereas in dogs biopterin presents the main part of pteridines (about 70%), cats contain about 53% catabolic isoxanthopterin in the pteridine pattern. In the various tumours no qualitative but quantitative alterations in the pteridine concentrations could be detected. The changes in the different tumours were not applied to all pteridines, so that each type of tumour shows an own pattern of pteridines.In the parvovirosis of the dog neopterin, biopterin and isoxanthopterin increased significantly. In the virusfree parvovirosis suspicious dogs only pterin was elevated. In the feline leucosis and feline infectious peritonitis a significant rise of all five measured pteridines were observed.Altogether, the data show, that increased urinary pteridines present a real additional aid for the suspicion of neoplasias or viral infections in the veterinary medicine.

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