In Vitro Susceptibility of Clinical Isolates of Aspergillus spp. to Anidulafungin, Caspofungin, and Micafungin: a Head-to-Head Comparison Using the CLSI M38-A2 Broth Microdilution Method

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Abstract
We determined the in vitro activities of anidulafungin, caspofungin, and micafungin against 526 isolates of Aspergillus spp. (64 A. flavus , 391 A. fumigatus , 46 A. niger , and 25 A. terreus isolates) collected from over 60 centers worldwide from 2001 through 2007. Susceptibility testing was performed according to the CLSI M38-A2 method. All three echinocandins—anidulafungin (50% minimum effective concentration [MEC 50 ], 0.007 μg/ml; MEC 90 , 0.015 μg/ml), caspofungin (MEC 50 , 0.015 μg/ml; MEC 90 , 0.03 μg/ml), and micafungin (MEC 50 , 0.007 μg/ml; MEC 90 , 0.015 μg/ml)—were very active against Aspergillus spp. More than 99% of all isolates were inhibited by ≤0.06 μg/ml of all three agents.
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