Comment: The Non-Hodgkin's Lymphomas

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Abstract
Many conceptual parallels in the diagnosis and treatment of non-Hodgkin's disease lymphomas have been stimulated by or derived from the Hodgkin's disease experience. The necessity for a unified classification of the anatomic extent of disease for all types of malignant lymphomas was presented earlier in this series. It is evident that the pathologic criteria and nomenclature must be reassessed in order to allow the clinician to decide on principles of management and recognize evolution of the disease. Rappaport67initiated identification of specific cell types in the lymphoproliferative and reticuloproliferative series, and gross nodal patterns of diffuse and nodular varieties. This plan has been adapted more recently by Lukes68and Butler69with the specific aim of eliminating the confusion caused by the terms lymphosarcoma and reticulum cell sarcoma (Table 4). The malignant lymphomas are divided into nodular and diffuse varieties with specific cell types: lymphocytic well differentiated and