In vivo stabilization of nuclear retinoid X receptor α in the presence of peroxisome proliferator‐activated receptor α

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Abstract
Retinoid X receptor α (RXRα) can reveal diverse functions through forming a heterodimer with peroxisome proliferator‐activated receptor α (PPARα). However, the mechanism of regulation of the cellular RXRα level is unclear. Thus, quantitative change of RXRα was investigated in mouse liver. Nuclear RXRα level was constitutively lower in PPARα‐null mice than in wild‐type mice. The level was also increased by clofibrate treatment in wild‐type mice without a concomitant increase of RXRα mRNA, but not in PPARα‐null mice. Pulse chase experiments demonstrated that the presence of PPARα and its activation by ligands significantly affected the stability of nuclear RXRα. These findings suggest a novel regulatory mechanism of nuclear RXRα in vivo.

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