DETECTABLE AMOUNTS OF ACTH IN BLOOD FOLLOWING SALICYLATE ADMINISTRATION

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Abstract
ALTHOUGH a tabulation (Hailman, 1952) of various physiological responses induced by cortisone, ACTH, and salicylate (SAL) suggests an ACTH mechanism of SAL effect, an increase in circulating ACTH following SAL has not been demonstrated. Because of our general interest in the effect of salicylate upon adrenal function and the probability that some, at least, of these effects may be mediated through the pituitary gland we have undertaken to determine, by the transfusion technique of Farrell and McCann (1952), whether SAL administration stimulates release of ACTH into the circulation.

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