Uterine activity and decidual prostaglandin production in women in early pregnancy in response to mifepristone with or without indomethacin in vivo
- 1 May 1991
- journal article
- research article
- Published by Oxford University Press (OUP) in Human Reproduction
- Vol. 6 (5) , 740-744
- https://doi.org/10.1093/oxfordjournals.humrep.a137420
Abstract
Mifepristone stimulates uterine activity in pregnant women in the first trimester. In-vitro studies have shown that the addition of mifepristone to culture medium increases the ability of decidual cells to generate prostaglandins. In this study, pregnant women of 2α (PGF2α) by decidua in vitro was increased. In the group in whom indomethacin was given in addition to mifepristone 36 h prior to the study, there was a marked reduction in the ability of decidua to generate PGF2α In spite of this suppression, the increase in uterine activity was similar to the group which had not received indomethacin. These results suggest that factors other than an increase in decidual prostaglandin production are responsible for the increase in uterine activity seen following mifepristone administration in vivo.Keywords
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