The Mechanism of CytochromeCReduction by Alkyl Radicals. Evidence for Multiple Reaction Pathways
- 1 January 1989
- journal article
- Published by Taylor & Francis in Free Radical Research Communications
- Vol. 6 (4) , 251-256
- https://doi.org/10.3109/10715768909073478
Abstract
The reactions of the hydroxyalkyl radicals .CH2OH and (CH3)2.COH with oxidized cytochrome c are for more complex than previously reported. Analysis of the pulse-radiolytic data by kinetic modelling revealed that only about 40% of the alkyl radicals reduce the ferric iron chromophore. Altogether, four different reactions have to be considered for the disappearance of the alkyl radicals, only two of which affect the metal site. The data show that these radicals, similar to the much more reactive hydrated electrons and hydrogen atoms, are capable to react with biological macromolecules in diverse ways.Keywords
This publication has 23 references indexed in Scilit:
- Reactivity of HO2/O−2 Radicals in Aqueous SolutionJournal of Physical and Chemical Reference Data, 1985
- Reactivity of semiquinone radicals and its relation to the biochemical role of superoxideJournal of the Chemical Society, Faraday Transactions 1: Physical Chemistry in Condensed Phases, 1982
- Reduction of ferricytochrome c, methemoglobin and metmyoglobin by hydroxyl and alcohol radicalsBiochimica et Biophysica Acta (BBA) - Protein Structure, 1979
- Fast electron transfer processes in cytochrome C and related metalloproteinsBiophysical Journal, 1978
- Correction to spectroelectrochemically determined rates for bipyridylium radical cation reactions with cytochrome C [1]Berichte der Bunsengesellschaft für physikalische Chemie, 1975
- Electron Transfer from Pyridinyl Radicals to Cytochrome‐cBerichte der Bunsengesellschaft für physikalische Chemie, 1975
- The mechanism of reduction of cytochrome c as studied by pulse radiolysisBiochimica et Biophysica Acta (BBA) - Bioenergetics, 1975
- Free radical reduction of ferricytochrome-cBiochemical and Biophysical Research Communications, 1975
- Reduction of ferricytochrome c by hydrogen atoms: Evidence for intramolecular transfer of reducing equivalentBiochimica et Biophysica Acta (BBA) - Bioenergetics, 1974
- Reduction of Ferricytochrome c by Some Free Radical AgentsScience, 1974