Partial primary structure of human pregnancy zone protein: extensive sequence homology with human alpha 2-macroglobulin.
- 1 December 1984
- journal article
- research article
- Published by Proceedings of the National Academy of Sciences in Proceedings of the National Academy of Sciences
- Vol. 81 (23) , 7353-7357
- https://doi.org/10.1073/pnas.81.23.7353
Abstract
Human pregnancy zone protein (PZP) is a major pregnancy-associated protein. Its quaternary structure (2 covalently bound 180-kDa [kilodalton] subunits, which are further non-covalently assembled into a tetramer of 720 kDa) is similar to that of human .alpha.2-macroglobulin (.alpha.2M). Complete or partial sequence determination of a random selection of 38 tryptic peptides covering 685 residues of the subunit of PZP showed that PZP and .alpha.2M indeed are extensively homologous. In the stretches of PZP sequenced so far, the degree of identically placed residues in the 2 proteins is 68%, indicating a close evolutionary relationship between PZP and .alpha.2M. Although the function of PZP in pregnancy is largely unknown, its close structural relationship to .alpha.2M suggests analogous proteinase binding properties and a potential for being taken up in cells by receptor-mediated endocytosis. In this regard these studies indicate a bait region in PZP significantly different from that present in .alpha.2M. PZP could be the human equivalent of the acute-phase .alpha.-macroglobulins (e.g., rat .alpha.2M and rabbit .alpha.1M) described earlier.This publication has 61 references indexed in Scilit:
- IMMUNOSUPPRESSION BY HUMAN α2‐MACROGLOBULIN, A 3800 Mr PEPTIDE, AND OTHER DERIVATIVESaAnnals of the New York Academy of Sciences, 1983
- Synthesis of α2‐macroglobulin in rat hepatocyte and in a cell‐free systemFEBS Letters, 1983
- Primary and secondary cleavage sites in the bait region of α2‐macroglobulinFEBS Letters, 1981
- A thiol‐ester in α2‐macroglobulin cleaved during proteinase complex formationFEBS Letters, 1980
- Isolierung und Charakterisierung des schwangerschafts-assoziierten ?2-Glykoproteins (?2PAG)Annals of Hematology, 1976
- Synthesis of a pregnancy-associatedα-macroglobulin by human leucocytesCellular and Molecular Life Sciences, 1975
- Inhibition of PHA‐induced lymphocyte stimulation by the pregnancy zone proteinFEBS Letters, 1973
- The isolation and partial characterisation of a new α‐macroglobulin from human pregnancy serumFEBS Letters, 1972
- Synthesis of α2-AP (Acute Phase) Globulin of Rat Serum by the LiverNature, 1966
- Synthesis of the α1-Glycoprotein (Darcy) of Rat Serum by the LiverNature, 1965