Difference in Biological Behavior Between Primate and Beef or Whale Pituitary Growth Hormones.

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Abstract
Growth hormones isolated from beef, whale, monkey and human pituitaries have been investigated with respect to their ability to elicit body-weight gain in hypophysectomized female rats. Whale and beef hormones elicited a continuous increase of body-weight for 90 days, whereas primate soma-totropins exerted this effect only for 10 days. After 10 days of injections with monkey or human hormones, animals became resistant to the effect of primate somatotropins, although no corresponding decrease in response to whale or bovine hormones was evident.