Effect of Splenectomy on Primary and Secondary Response to Sheep Erythrocytes in Rats

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Abstract
Splenec-tomy 1 day before antigen will inhibit completely the response to in-travenously injected sheep red blood cells, and will depress the re-sponse below normal levels when performed 8 or 14 days after anti-gen. Secondary response is inhibited by splenectomy prior to the 2nd injection of antigen. This appears to be different from results obtained with Salmonella typhi flagellar antigen, in which no effect of splenectomy on secondary response can be demonstrated. This suggests that the anamnestic response to intravenous injections of sheep red blood cells depends on the presence of the spleen.