Synthesis of disulfates of unconjugated and conjugated bile acids.
- 1 January 1987
- journal article
- research article
- Published by Pharmaceutical Society of Japan in CHEMICAL & PHARMACEUTICAL BULLETIN
- Vol. 35 (11) , 4562-4567
- https://doi.org/10.1248/cpb.35.4562
Abstract
The disulfates of unconjugated, and glycine- and taurine-conjugated bile acids have been synthesized. Cholic acid derivatives appropriately protected were sulfated with sulfur trioxide-triethylamine complex in pyridine in the usual manner. Subsequent hydrolysis and/or sodium borohydride reduction provided the desired disulfates of cholates in satisfactory yields. Dihydroxylated bile acid disulfates were aso prepared. The nuclear magnetic resonance spectral data for bile acid disulfates and related compounds are tabulated.This publication has 4 references indexed in Scilit:
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- Bile acid sulfates. III. Synthesis of 7- and 12-monosulfates of bile acids and their conjugates using a sulfur trioxide-triethylamine complexSteroids, 1979
- Synthesis of monosulfates of unconjugated and conjugated bile acids.CHEMICAL & PHARMACEUTICAL BULLETIN, 1979