THE VALUE OF NEEDLE BIOPSY IN THE CHEMICAL ESTIMATION OF LIVER LIPIDS IN MAN 1

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Abstract
Methods are descr. for chemical analysis of the percentage of dry matter, total lipids, total fatty acids and their iodine number, and phos-pholipids in specimens of liver tissue obtained by needle biopsy. 18 such specimens taken from different sites in each of 25 postmortem livers (13-non-fatty and 12 fatty) were examined histologi-cally and their total lipid concn. detd. chemically. The variation in the different samples is reported and the effect of cirrhosis in the findings discussed. Good correlation was found between histological and chemical findings and relative uniformity in the distr. of lipids throughout the liver observed. Approx. limits of error in estimating the lipid concn. of the whole liver from analysis of a simple biopsy specimen are given Factors are given for use in determining whether the value for lipid concn. of a repeat biopsy specimen indicates a significant change in the lipid concn. of the whole liver.