The effect of high or low dietary calcium on bone and calcium homeostasis in young male rats
- 1 June 1993
- journal article
- laboratory investigations
- Published by Springer Nature in Calcified Tissue International
- Vol. 52 (6) , 460-464
- https://doi.org/10.1007/bf00571337
Abstract
Young male rats (100 g body weight) were fed diets containing varying amounts of calcium. Body weight and bone development were studied together with various endocrine parameters, including blood levels of Ca2+, calcitonin, parathyroid hormone, vitamin D, and gastrin, and the enterochromaffin-like (ECL) cell-related parameters gastric mucosal histidine decarboxylase activity and histamine concentration. A diet containing 0.5% calcium resulted in ontimum body weight gain and bone development. A lower calcium intake impaired body weight gain and bone development. The impairment was manifested in reduced bone calcium content whereas the size of the bones was unaffected. The net absorption of calcium seemed to be proportional to the calcium intake. A low calcium diet (0.03%) raised the circulating levels of 1,25(OH)2D and parathyroid hormone and lowered 25(OH)D3 and Ca2+, whereas a high calcium diet (5.46%) raised calcitonin, Ca2+, 25(OH)D3, and 1,25(OH)2D. In addition, the low calcium diet lowered the circulating gastrin concentation and the histidine decarboxylase activity and histamine content of the ECL cells in the gastric mucosa. A high calcium diet raised the circulating gastrin concentration, but the rise was not associated with an increase in the histidine decarboxylase activity and histamine content.Keywords
This publication has 23 references indexed in Scilit:
- Importance of the stomach in maintaining calcium homoeostasis in the rat.Gut, 1991
- Calcium supplementation of the diet: justified by present evidence.BMJ, 1990
- Elevated serum gastrin after food intake or acid blockade evokes hypocalcemiaRegulatory Peptides, 1990
- Evidence that gastrin enhances 45Ca uptake into bone through release of a gastric hormoneRegulatory Peptides, 1990
- Gastrin releases a blood calcium-lowering peptide from the acid-producing part of the rat stomach.Proceedings of the National Academy of Sciences, 1989
- Calcium supplementation of the diet--I.BMJ, 1989
- Cholecystokinins but not gastrin-17 release calcitonin from thyroid C-cells in the ratRegulatory Peptides, 1988
- A simplified procedure for the fluorometric determination of histamine in rat stomachInflammation Research, 1984
- Evaluation by Radioimmunoassay of Factors Controlling the Secretion of Parathyroid Hormone: Perfusion of the Isolated Parathyroid Gland of the Goat and SheepNature, 1966
- Evaluation by Radioimmunoassay of Factors Controlling the Secretion of Parathyroid Hormone: Intravenous Infusions of Calcium and Ethylenediamine Tetraacetic Acid in the Cow and GoatNature, 1966