Adverse Reactions to Methicillin and Nafcillin During Treatment of Serious Staphylococcus aureus Infections
- 1 June 1978
- journal article
- research article
- Published by American Medical Association (AMA) in Archives of internal medicine (1960)
- Vol. 138 (6) , 909-911
- https://doi.org/10.1001/archinte.1978.03630310009008
Abstract
Relative toxicities of methicillin and nafcillin were compared in 70 patients with serious infections caused by Staphylococcus aureus. Of the 29 patients treated with nafcillin, four had fever, rash, and leukopenia and 1 had absolute neutropenia. Of the 41 patients treated with methicillin, 16 experienced 27 reactions. In addition to fever and skin rash, neutropenia and urinary tract abnormalities were common. Methicillin and nafcillin are equally effective in treating S aureus infections, but methicillin was significantly and more frequently associated with adverse drug reaction that was nafcillin. (Arch Intern Med 138:909-911, 1978)This publication has 5 references indexed in Scilit:
- Staphylococcal endocarditis in drug users. Clinical and microbiologic aspectsArchives of internal medicine (1960), 1975
- Comparative Synergistic Activity of Nafcillin, Oxacillin, and Methicillin in Combination with Gentamicin Against EnterococciAntimicrobial Agents and Chemotherapy, 1975
- Hyperimmunoglobulinemia associated with narcotic addiction: Effects of methadone maintenance treatmentThe American Journal of Medicine, 1973
- Clinical pharmacology of the new penicillins: I. The importance of serum protein binding in determining antimicrobial activity and concentration in serumClinical Pharmacology & Therapeutics, 1966
- Bone-Marrow Depression Resulting from the Administration of MethicillinNew England Journal of Medicine, 1962