THE METABOLISM OF CALCIUM AND PHOSPHORUS AS INFLUENCED BY THE ADDITION TO THE DIET OF SALTS OF METALS WHICH FORM INSOLUBLE PHOSPHATES

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Abstract
The type of rickets produced by the addition to the diet of metals which form an insoluble phosphate can be prevented or cured by large doses of irradiated ergosterol as judged by calcification at the metaphyses. Although the serum phosphate was raised and the amt. and % of bone ash increased the Vit. D failed to produce normal calcification. The addition to the diet of metals which form an insoluble phosphate did not decrease the toxicity of large doses of irradiated ergosterol. BeCO3 added to the diet produced very low levels of serum phosphate but there was no reciprocal rise in Ca. If Be or Al salts were added to a high Ca rickets-producing diet the Ca could be dropped out without change in the Ca and phosphate levels of the serum and without the occurrence of tetany. 5% Al sulfate given for a period of 3 mos. produced a marked decrease in serum phosphate and nearly 1/3 of the mineral constituents of the skeleton were lost. There was no rise in serum Ca.

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