Internuclear cyclisation. Part XXIX. Oxidation of some N-methylbiphenyl-2-carboxamides with persulphate
- 1 January 1972
- journal article
- Published by Royal Society of Chemistry (RSC) in Journal of the Chemical Society, Perkin Transactions 1
- p. 118-124
- https://doi.org/10.1039/p19720000118
Abstract
Oxidations of 2′-, 3′-, and 4′-methoxy-N-methylbiphenyl-2-carboxamides by potassium persulphate have been studied. Cyclisation to γ-lactams as well as the expected phenanthridinones is found to be important, particularly in alkaline solution. Similar oxidation of N-methylbiphenyl-2-carboxamide itself in alkaline solution in the presence of oxygen gives some of the γ-lactam-dienone (16) in addition to N-methylphenanthridinone. Persulphate oxidation of 3-methoxy-N-methylphenanthridinone gives the biphenanthridinone (20).Keywords
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