THE RÔLE OF INTRACELLULAR BACTERIOPHAGE IN LYSIS OF SUSCEPTIBLE STAPHYLOCOCCI

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Abstract
Exps. with a satisfactory quantitative technique for determination of phage/ml. indicate that the significant condition for bacterial lysis is either a concentration of about 110 phage units inside each bacterium or of about 12 X 108 phage units in each ml. of surrounding solution. These 2 quantities are always in constant ratio to each other; it is, therefore, immaterial which one is used in defining the lytic threshold. Evidently, also, they can not be distinguished by any experimental procedure carried out under equilibrium conditions. It seems likely that the internal phage is responsible for the reaction.

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