Biology and pharmacology of recombinant human interleukin-1β-induced rat ear inflammation
- 1 August 1987
- journal article
- Published by Springer Nature in Inflammation Research
- Vol. 21 (3-4) , 325-327
- https://doi.org/10.1007/bf01966505
Abstract
A single, 10 ng intradermal injection of human recombinant interleukin-1β (rIL-1β) into rat ears produced acute inflammation. Tissue wet weight (edema) and total myeloperoxidase activity (PMN accumulation), peaked at 3 hours and returned to base line at 3 days. Given orally, 1 hour prior to rIL-1β injection, cyproheptadine, dexamethasone, conventional NSAID's, or mixed cyclooxygenase/lipoxygenase inhibitors were potent antagonists of edema and moderate antagonists of PMN accumulation. In addition, the putative DMARD's, auranofin, dapsone, and levamisole were effective inhibitors of rIL-1β induced inflammation.Keywords
This publication has 8 references indexed in Scilit:
- Modulation of the release of histamine and arachidonic acid metabolites from human basophils and mast cells by auranofinInflammation Research, 1986
- In vivo inflammatory activity of epidermal cell-derived thymocyte activating factor and recombinant interleukin 1 in the mouse.Journal of Clinical Investigation, 1986
- Cultured human vascular endothelial cells acquire adhesiveness for neutrophils after stimulation with interleukin 1, endotoxin, and tumor-promoting phorbol diesters.The Journal of Immunology, 1986
- Normal epidermis contains high amounts of natural tissue IL 1 biochemical analysis by HPLC identifies a MW approximately 17 Kd form with a P1 5.7 and a MW approximately 30 Kd form.1986
- The role of arachidonic acid metabolism in the activities of interleukin 1 and 2.The Journal of Immunology, 1985
- Measurement of Cutaneous Inflammation: Estimation of Neutrophil Content with an Enzyme MarkerJournal of Investigative Dermatology, 1982
- Sulfonamides and Sulfones in Dermatologic TherapyInternational Journal of Dermatology, 1981