Sodium and Seizures
- 1 June 1964
- Vol. 5 (2) , 97-111
- https://doi.org/10.1111/j.1528-1157.1964.tb03320.x
Abstract
SUMMARY: The intraventricular administration of hypertonic sodium chloride may induce seizure activity both behaviorally and electrographically from rhinencephalic and caudate nuclei and diencephalon, while no such changes occur with isotonic saline and similar hyperosmolar sugar solutions. An initial extraneuronal, then intraneuronal increase of sodium may be so produced and account for the development of a hyper‐excitable state.RÉSUMÉ: L'administration intraventriculaire de chloride de sodium hypertonique peut induire une activité de crises du comportement en même temps qu'électrographiquement des noyaux rhinencéphalique et caudé et du diencéphale, tandis que pareils changements ne se produisent pas quand il s'agit d'une solution saline isotonique et d'une solution semblable de sucre hyperosmolaire. Une augmentation initiate extraneurale, puis intraneurale de sodium peut s'être produite et expliquer le développement d'un état hyperexcitable.Keywords
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