Reed-Sternberg cells in Hodgkin's disease contain fibronectin
Open Access
- 1 February 1981
- journal article
- Published by American Society of Hematology in Blood
- Vol. 57 (2) , 339-342
- https://doi.org/10.1182/blood.v57.2.339.339
Abstract
Reed-Sternberg cells in the lymph nodes from five patients with Hodgkin's disease were studied. Indirect immunofluorescence on fixed sections with a monospecific anti-serum to fibronectin revealed abundant cytoplasmic fibronectin in approximately 90% of the Reed- Sternberg cells. In addition, the cells were shown by immunofluorescence to contain polyclonal IgG; however, factor VIII antigen, albumin, fibrinogen, alpha-2-macroglobulin, anti-thrombin III, and ceruloplasmin were not present. The abundant cytoplasmic fibronectin suggests that Reed-Sternberg cells are derived from tissue macrophages.Keywords
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