Genetic Control of Natural Resistance of Mouse Macrophages to Coxiella burnetii Infection In Vitro: Macrophages from Restrictive Strains Control Parasitophorous Vacuole Maturation
Open Access
- 1 April 2004
- journal article
- Published by American Society for Microbiology in Infection and Immunity
- Vol. 72 (4) , 2395-2399
- https://doi.org/10.1128/iai.72.4.2395-2399.2004
Abstract
Macrophages from A/J and BALB/c mice were more susceptible to Coxiella burnetii phase II infection than were those from C57BL/6, C57BL/10, B10.A, C3H/HePas, and Swiss mice. Resistant macrophages effectively controlled the development of large replication vacuoles (LRVs), which accounted for the restriction of bacterial multiplication within the cultures. However, compared to fibroblasts, all macrophages controlled bacterial multiplication within LRVs.Keywords
This publication has 22 references indexed in Scilit:
- Coxiella burnetii express type IV secretion system proteins that function similarly to components of the Legionella pneumophila Dot/Icm systemMolecular Microbiology, 2003
- Nitric Oxide Partially ControlsCoxiella burnetiiPhase II Infection in Mouse Primary MacrophagesInfection and Immunity, 2003
- Chromosomal DNA Deletions Explain Phenotypic Characteristics of Two Antigenic Variants, Phase II and RSA 514 (Crazy), of theCoxiella burnetiiNine Mile StrainInfection and Immunity, 2002
- Coxiella burnetii Localizes in a Rab7-Labeled Compartment with Autophagic CharacteristicsInfection and Immunity, 2002
- Immunity to intracellular pathogens as a complex genetic traitCurrent Opinion in Microbiology, 2002
- Developmental biology of Coxiella burnetiiTrends in Microbiology, 1999
- Biosafety concerns and Coxiella burnetiiTrends in Microbiology, 1996
- Survival of the Q fever agent Coxiella burnetii in the phagolysosomeTrends in Microbiology, 1994
- Genetic control of host resistance to infectionTrends in Genetics, 1994
- Animal Models in Q Fever: Pathological Responses of Inbred Mice to Phase I Coxiella burnetiiMicrobiology, 1987