Liver‐directed overexpression of mitochondrial glycerol‐3‐phosphate acyltransferase results in hepatic steatosis, increased triacylglycerol secretion and reduced fatty acid oxidation
Open Access
- 10 January 2006
- journal article
- research article
- Published by Wiley in The FASEB Journal
- Vol. 20 (3) , 434-443
- https://doi.org/10.1096/fj.05-4568com
Abstract
Glycerol-3-phosphate acyltransferase (GPAT) catalyzes the first committed step in triacylglycerol (TAG) and phospholipid biosynthesis. GPAT activity has been identified in both ER and mitochondrial s...Keywords
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