Effect of Intraventricular Administration of Antisomatostatin γ-Globulin on the Lethal Dose-50 of Strychnine and Pentobarbital in Rats*

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Abstract
Effects of intraventricular injection of sheep anti-somatostatin .gamma.-globulin (anti-SSG) on strychnine-induced seizures, strychnine LD50, and pentobarbital LD50 were examined in male rats under light ether anesthesia. Anti-SSG [10 .mu.l] given 2 h earlier significantly decreased the duration of strychnine-induced seizures as compared with that in the control rats pretreated with normal sheep .gamma.-globulin (NSG). This effect of anti-SSG seemed to be specific, as there was no difference in seizure duration between sheep anti-LHRH [luteinizing hormone releasing hormone] .gamma.-globulin (anti-LHRHG)- and NSG-pretreated rats. Survival rates in anti-SSG-pretreated rats after injection of strychnine and pentobarbital with significantly larger (P < 0.01 and P < 0.05, respectively) than those in the control rats receiving in 26.7% and 22.9% increases in the LD50 of strychnine and pentobarbital, respectively. Apparently, endogenous somatostatin in the cerebrospinal fluids and/or the periventricular tissue, modulates the response of the central nervous system to strychnine and pentobarbital in rats.