Further studies on the hydrolysis of salicyluric acid in intestinal microorganisms and prolonged blood concentration of salicylic acid following rectal administration of salicyluric acid in rabbits.
- 1 January 1988
- journal article
- research article
- Published by Pharmaceutical Society of Japan in Journal of Pharmacobio-Dynamics
- Vol. 11 (1) , 53-57
- https://doi.org/10.1248/bpb1978.11.53
Abstract
The blood concentrations of salicyluric acid and salicylic acid following intracecal and rectal administration of salicyluric acid were determined in rabbits. Immediate and very extensive salicylic acid formation in the cecum was found following intraceal administration. After rectal administration, a small amount of salicyluric acid was absorbed in intact form. The rest was rapidly hydrolyzed to salicylic acid, which was subsequently absorbed. The blood concentration of salicylic acid was maintained at 1.3-1.8 .mu.g/ml from 2 to 12 h. Three doses of salicyluric acid were administered rectally. The peak level of salicyluric acid increased with dose. However, salicylic acid concentration in the blood following administration of salicyluric acid at 10.0 mg/kg (salicylic acid equivalent) was not double that observed following administration of salicyluric acid at 5.0 mg/kg (salicylic acid equivalent). It appears that a larger amount of salicyluric acid in the rectal lumen may have saturated the glycine deconjugation system.This publication has 5 references indexed in Scilit:
- Hydrolysis of salicyluric acid in rabbit intestinal microorganisms.Journal of Pharmacobio-Dynamics, 1985
- Drug glycosides: potential prodrugs for colon-specific drug deliveryJournal of Medicinal Chemistry, 1985
- A colon-specific drug-delivery system based on drug glycosides and the glycosidases of colonic bacteriaJournal of Medicinal Chemistry, 1984
- Simultaneous liquid-chromatographic quantitation of salicylic acid, salicyluric acid, and gentisic acid in plasma.Clinical Chemistry, 1979
- The metabolism of p-aminohippuric acid and p-acetylamino-hippuric acidClinica Chimica Acta; International Journal of Clinical Chemistry, 1967