THE BIOLOGICAL HALF-LIVES OF 4 RAT IMMUNOGLOBULIN ISOTYPES
- 1 January 1980
- journal article
- research article
- Vol. 40 (4) , 683-686
Abstract
Purified preparations of monoclonal rat Ig[immunoglobulin]G2a, IgG1, IgM and monomeric IgA, and of polyclonal IgG, were lightly radiolabeled with 125I and injected i.v. into rats. Blood samples were taken so that the half-life of each Ig isotype could be calculated. Half-life was defined as the time taken for the specific radioactivity present in the blood 24 h after injection to fall by half. The half-life values were 106 h for IgG2a, 53 h for IgG1, 63 h for polyclonal IgG, 25 h for IgM and 27 h for monomeric IgA.This publication has 10 references indexed in Scilit:
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