Enzymatic deacylation of the lipid A moiety of Salmonella typhimurium lipopolysaccharides by human neutrophils.
- 1 November 1983
- journal article
- research article
- Published by Proceedings of the National Academy of Sciences in Proceedings of the National Academy of Sciences
- Vol. 80 (21) , 6671-6675
- https://doi.org/10.1073/pnas.80.21.6671
Abstract
The granule fraction of human neutrophils contains .gtoreq. 1 enzymes that partially deacylate S. typhimurium lipid A by removing the nonhydroxylated fatty acids, leaving almost all of the 3-hydroxytetradecanoic acid residues linked to glucosamine. Evidently, similar reactions occur in living neutrophils that ingest lipopolysaccharides by antibody-dependent phagocytosis.This publication has 22 references indexed in Scilit:
- The accessory function of phagocytic cells in human T cell and B cell responses.The Journal of Immunology, 1982
- The Chemical Structure of Lipid AEuropean Journal of Biochemistry, 1982
- Phenacyl esters of fatty acids via crown ether catalysts for enhanced ultraviolet detection in liquid chromatographyAnalytical Chemistry, 1975
- Phospholipid metabolism by phagocytic cellsBiochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism, 1972
- [Enzymatic liberation of long-chain fatty acids from bacterial lipopolysaccharides with the aid of extracts from amoebae of Dictyostelium discoideum].1970
- A New Method for the Extraction of R LipopolysaccharidesEuropean Journal of Biochemistry, 1969
- Molecular aspects of endotoxic reactions.1969
- The interaction of Escherichia coli endotoxin with leukocytesArchives of Biochemistry and Biophysics, 1969
- Isolation of mononuclear cells and granulocytes from human blood. Isolation of monuclear cells by one centrifugation, and of granulocytes by combining centrifugation and sedimentation at 1 g.1968
- Fatty Acid Biosynthesis in Human Leukocytes*Journal of Clinical Investigation, 1967