The Role of T H 1 and T H 2 Cells in a Rodent Malaria Infection
- 25 June 1993
- journal article
- other
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 260 (5116) , 1931-1934
- https://doi.org/10.1126/science.8100366
Abstract
CD4 + T cells play a major role in protective immunity against the blood stage of malaria, but the mechanism of protection is unclear. By adoptive transfer of cloned T cell lines, direct evidence is provided that both T H 1 and T H 2 subsets of CD4 + T cells can protect mice against Plasmodium chabaudi chabaudi infection. T H 1 cells protect by a nitric oxide-dependent mechanism, whereas T H 2 cells protect by the enhancement and accelerated production of specific immunoglobulin G1 antibody.Keywords
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