Microsatellite Instability Generates Diversity in Brain and Sociobehavioral Traits
Top Cited Papers
- 10 June 2005
- journal article
- other
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 308 (5728) , 1630-1634
- https://doi.org/10.1126/science.1111427
Abstract
Repetitive microsatellites mutate at relatively high rates and may contribute to the rapid evolution of species-typical traits. We show that individual alleles of a repetitive polymorphic microsatellite in the 5′ region of the prairie vole vasopressin 1a receptor ( avpr1a ) gene modify gene expression in vitro. In vivo, we observe that this regulatory polymorphism predicts both individual differences in receptor distribution patterns and socio-behavioral traits. These data suggest that individual differences in gene expression patterns may be conferred via polymorphic microsatellites in the cis-regulatory regions of genes and may contribute to normal variation in behavioral traits.Keywords
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