Central nervous system depressants. 14. As‐triazino‐1,4‐benzodiazepines

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Abstract
Seven series of as‐triazino[4,3‐a] [1,4]benzodiazepines were prepared which differed in the degree of unsaturation or the nature and position of oxygen function on the triazino ring. These were prepared by closing the triazino ring of appropriately substituted hydrazones from 2‐hydrazinobenzodiazepines or by condensing substituted hydrazines with 2‐thiobenzodiazepines. Most of these represent new ring systems. They were tested in a battery of tests designed to uncover central nervous system activities. Most of the activity was found in tests thought to be indicative of anxiolytic, hypnotic or sedative potential. Five of the series contained members more active than the standard, diazepam, and a few of the compounds were among the most potent benzodiazepines known. Some of the intermediate benzodiazepine hydrazones were also active.