Biocatalytic Production of Chiral Pharmaceutical Intermediates
- 1 January 2000
- journal article
- research article
- Published by Taylor & Francis in Biocatalysis and Biotransformation
- Vol. 18 (2) , 105-118
- https://doi.org/10.3109/10242420009015240
Abstract
Biocatalytic production of several key chiral intermediates in the synthesis of anti-inflammatory, anti-viral and anti-leukaemic agents is described. These include (i) a nucleoside oxidase from Stenotrophomonas maltophilia to oxidise unnatural purine nucleosides, (ii) a serine-type protease from an alkalophilic Bacillus sp. to resolve racemic N-substituted lactams, and (iii) a co-immobilised uridine phosphorylase and purine nucleoside phosphorylase preparation from recombinant E. coli strains that catalyse base transfer reactions.Keywords
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