Relation between Respiratory Function and Pulmonary Hemodynamics before and after Intravenous Administration of Furosemide in Acute Myocardial Infarction

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Abstract
Static lung volumes, flow volume curve in air and in a He-O2 mixture, PaO2 [arterial O2 pressure] and pulmonary vascular pressures were measured in 16 patients 2 wk after uncomplicated acute myocardial infarction and repeated 2 h after furosemide 40 mg i.v. administration. The patients with wedge pressure .**GRAPHIC**. < 18 mm Hg had significantly lower values of FEV1 [forced expiratory volume], FEV1/VC%, MEF50 [maximum expiratory flow at 50% vital capacity] and MEF25 [maximum expiratory flow at 25% vital capacity] in comparison with the patients with .**GRAPHIC**. 18 mm Hg. A negative correlation was found between both .**GRAPHIC**. [pulmonary artery pressure] and .**GRAPHIC**. and MEF25 values (P < 0.001). After furosemide, respiratory function tests improved only in patients with good hemodynamic response to the drug. PaO2 did not change significantly. Airflow response to He seemed to be a useful test for determining the site of major bronchial compression.

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