PATTERNS OF CELL-PROLIFERATION AND CELL-MIGRATION IN THE SEZARY SYNDROME

  • 1 January 1981
    • journal article
    • research article
    • Vol. 57  (3) , 452-463
Abstract
The patterns of cell proliferation and cell migration were studied in 3 patients with the Sezary syndrome using autoradiographic techniques. Cell labeling patterns following pulse labeling with tritiated thymidine in vivo indicated that Sezary cells proliferate actively in skin and in lymph nodes, but that few if any Sezary cells proliferate in the peripheral blood. In 2 patients serial samples were obtained. Label dilution patterns in skin and blood over time suggested that circulating Sezary cells originated in extracutaneous sites in which cells were proliferating more rapidly than in the skin. Cells labeled in extracutaneous sites of proliferation appear rapidly in the blood, and their transit-time through the peripheral blood compartment is short. Circulating Sezary cells may then be deposited in the skin where they resume proliferation at a low rate. While Sezary cells proliferate in cutaneous and extracutaneous sites, proliferation appears to be more rapid in extracutaneous sites, such as lymph nodes. This suggests that trials of systemic therapeutic approaches should be undertaken.