Xylazine‐induced mydriasis: possible involvement of a central postsynaptic regulation of parasympathetic tone
- 1 September 1981
- journal article
- Published by Wiley in Journal of Veterinary Pharmacology and Therapeutics
- Vol. 4 (3) , 209-214
- https://doi.org/10.1111/j.1365-2885.1981.tb00731.x
Abstract
Intravenous injection of xylazine (0.01 – 1 mg/kg) produced a dose‐dependent mydriasis associated with a depression of tonic ciliary nerve activity in anesthetized cats. Xylazine‐induced mydriasis was apparent in the sympathectomized iris but was absent in the parasympathectomized, physostigmine‐treated iris. Epinephrine (30 μg/kg, i.v.) produced a slighdy greater mydriasis in the sympathectomized iris than in the parasympathectomized, physostigmine‐treated iris. The α2‐adrenergic blocking agent, yohimbine (0.5 mg/kg, i.v.) antagonized the pupillary dilation and reversed the depression of ciliary nerve activity induced by xylazine administration.In rats pretreated with reserpine (7.5 mg/kg, s.c., 20 h) and α‐methyl‐p‐tyrosine (250 mg/kg, i.p., 5 h), intravenous injection of xylazine (0.01 – 1 mg/kg) resulted in mydriasis of similar magnitude as control animals. However, xylazine induced bradycardia in the control group but not in die pretreated animals.The results suggest that pupillary dilation produced by i.v. xylazine is primarily die result of a central inhibition of parasympathetic tone to the iris. It also appears that xylazine produces this effect via postsynaptic α2‐adrenergic mechanisms, while it produces bradycardia through a presynaptic α2‐adrenergic mechanism.Keywords
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