CORTICOTROPIN-INDUCED ALKALOSIS IN THE WEANLING RAT AND ITS RELATION TO THE BALANCE OF NON-METABOLIZABLE BASE

  • 1 January 1983
    • journal article
    • research article
    • Vol. 43  (1) , 73-83
Abstract
Studies of whole body balances of nonmetabolizable base (NB) and several electrolytes and of the acid-base status of blood and urine during development of ACTH-induced alkalosis in the weanling rat were carried out to identify the primary source of base and factors instrumental in maintenance of the alkalotic state. The data were compared to baseline and running control values and to the results of whole carcass analyses. Primary accumulation of NB was accounted for by ongoing gastrointestinal NB absorption in the weight-losing animal, distributed to extracellular and non-extracellular compartments of the body. An increase in the rate of renal excretion of non-metabolizable acid (NA), from negative values to zero, corresponded to an increased load of endogenous sulfuric acid and a reduced rate of gastrointestinal NB absorption. Accordingly, the renal response did not per se contribute to the induction of extracellular alkalosis. Maintenance of alkalosis occurred in spite of ample chloride in the renal tubular lumen and a moderate increase in relative extracellular volume. In the absence of evidence of overloading (with base) or malfunction of the kidney, ACTH induced alkalosis is classifiable as a ''set-point disturbance'' of acid-base metabolism in which fluctuations in the (non-renal) load of NA lead to commensurate changes in renal NA excretion at an elevated extracellular pH. Withdrawal of ACTH injections was followed by prompt restoration of a normal extracellular acid-base status and a return to reference values for renal NA excretion despite a marked fall in the balance of NB. This observation supports a concept of the extracellular compartment as the immediate reference system of the kidney.