Insertion of spliceosomal introns in proto‐splice sites: the case of secretory signal peptides
- 11 September 2004
- journal article
- Published by Wiley in FEBS Letters
- Vol. 575 (1-3) , 109-111
- https://doi.org/10.1016/j.febslet.2004.08.045
Abstract
Analysis of the exon–intron structures of 2208 human genes has revealed that there is a statistically highly significant excess of phase 1 introns in the vicinity of the signal peptide cleavage sites. It is suggested that amino acid sequences surrounding signal peptide cleavage sites are significantly enriched in phase 1 proto‐splice sites and this has favored insertion of spliceosomal introns in these sites.Keywords
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