Hallmarks of 'BRCAness' in sporadic cancers
Top Cited Papers
- 1 October 2004
- journal article
- research article
- Published by Springer Nature in Nature Reviews Cancer
- Vol. 4 (10) , 814-819
- https://doi.org/10.1038/nrc1457
Abstract
Germline mutations in the BRCA1, BRCA2 and Fanconi anaemia genes confer cancer susceptibility, and the proteins encoded by these genes have distinct functions in related DNA-repair processes. Emerging evidence indicates that these processes are disrupted by numerous mechanisms in sporadic cancers. Collectively, there are properties that define 'BRCAness' — that is, traits that some sporadic cancers share with those occurring in either BRCA1- or BRCA2-mutation carriers. These common properties might have important implications for the clinical management of these cancers.Keywords
This publication has 58 references indexed in Scilit:
- A census of human cancer genesNature Reviews Cancer, 2004
- Inactivation of the Fanconi anemia/BRCA pathway in lung and oral cancers: implications for treatment and survivalOncogene, 2003
- Stem cells and breast cancer: A field in transitNature Reviews Cancer, 2003
- Germline BRCA1 Mutations and a Basal Epithelial Phenotype in Breast CancerJNCI Journal of the National Cancer Institute, 2003
- A novel ubiquitin ligase is deficient in Fanconi anemiaNature Genetics, 2003
- Repeated observation of breast tumor subtypes in independent gene expression data setsProceedings of the National Academy of Sciences, 2003
- Disruption of the Fanconi anemia–BRCA pathway in cisplatin-sensitive ovarian tumorsNature Medicine, 2003
- Gene expression profiling predicts clinical outcome of breast cancerNature, 2002
- Gene expression patterns of breast carcinomas distinguish tumor subclasses with clinical implicationsProceedings of the National Academy of Sciences, 2001
- The Hallmarks of CancerCell, 2000