Natural history of blue sclerae in osteogenesis imperfecta
- 15 January 1993
- journal article
- Published by Wiley in American Journal of Medical Genetics
- Vol. 45 (2) , 183-186
- https://doi.org/10.1002/ajmg.1320450207
Abstract
Scleral hue is an important sign which distinguishes 2 broad groupings of patients, those with and those without blue sclerae with non‐lethal osteogenesis imperfecta (OI). Individuals with OI type I have distinctly blue sclerae which remain intensely blue throughout life. In OI type III and OI type IV the sclerae may also be blue at birth and during infancy, but the intensity fades with time such that these individuals have sclerae of normal hue by adolescence and adult life.Keywords
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