Plasma Levels of Clobazam After Three Oral Dosage Forms in Healthy Subjects

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Abstract
The terminal half-life of clobazam, a mild tranquilizer, is about 50 h and from a solid dosage form the peak plasma level occurs approximately 1.5 h after ingestion in humans. There is a significant, yet relatively short, dosage form delay effect when the solid dosage forms are compared to the rapidly available solution of the drug. Based on the areas under the curve, comparison of the solid dosage forms with the solution indicates that the fraction of clobazam absorbed is 1. Pupil diameter measurement at 2, 4 and 6 h after ingestion of clobazam correlated well with the plasma levels at these times. Pupils were constricted to the highest degree at 2 h and approached the initial pupillary diameter at the 6 h measurement.