A study of factors affecting the rates of hydrolysis of some N-arylazetidin-2-ones (N-aryl-β-lactams)

Abstract
One of the characteristics of the penam system is the ease with which the β-lactam ring undergoes hydrolytic ring opening. From a study of the rates of hydrolysis of various N-arylazetidin-2-ones it has been concluded that anchimeric assistance from an amido-group at the 3-position and angle strain imposed by a spiro-group at the 4-position are not important factors in causing this.

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