A note on saturable and inhibitory kinetics of p-aminohippurate renal transport in rabbits.

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Abstract
To establish quantitative expressions of inhibitory kinetics in renal tubular secretion of p-aminohippurate (PAH), bolus i.v. injection and constant i.v. infusion of PAH were given to rabbits. Time courses of plasma concentration and urinary excretion rate were analyzed using a compartment model with saturable rate process. Effects of sulfamethizole (SMZ) constant infusion and bolus injection on PAH renal excretion were also examined. Multi-compartment model for concurrent disposition of PAH and SMZ is presented. Excretory processes are composed of non-saturable filtration, saturable secretion which is subject to mutual inhibition and reabsorption.

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