A Study on Pigment Deposition by Intravenous Fat Emulsions

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Abstract
Eleven fat emulsions containing various synthetic or vegetable oils were administered intravenously to rabbits or rats. In addition the emulsifying systems without fat were similarly tested. A pigment-lipoid complex, i.v. fat pigment, was found within the cytoplasm of the splenic reticuloendothelial cells of animals receiving coconut oil-phosphatide, cottonseed oil-nonphosphatide, cottonseed oil-phosphatide, molecularly distilled cottonseed oil-phosphatide, olive oil-phosphatide, corn oil-phosphatide, peanut oil-phosphatide, butyro olein-phosphatide, safflower oil-phosphatide or synthetic oil-nonphosphatide emulsions. No i.v. fat pigment was observed in animals receiving coconut oil-nonphosphatide emulsion or in the animals receiving the emulsifying mixture without fat.