Similar rate of progression in the predialysis phase in type I and type II diabetes mellitus

Publisher Website
Google Scholar
Abstract
Progression of diabetic nephropathy from the stage of macroproteinuria with near-normal renal function until start of dialysis was compared in 16 patients with type I and 16 patients with type II diabetes mellitus. The mean creatinine clearance at the beginning of the study was 89±13 ml/min/l.73 m2 in patients with type I and 81±6 ml/min/1.73 m in those with type II diabetes. Dialysis was started after a mean interval of 77(44–133) months, when creatinine clearance had decreased to 8 ± 2 ml/min/1.73 m2 in type I diabetic patients. The respective figures for type II diabetic patients were 81(40–124) months and 7±2 ml/min/1.73 m2 The mean rate of decrease in creatinine clearance was 1.05 ± 0.45 ml/min/month in type I and 0.91 ± 0.41 ml/min/month in type II diabetes. The mean rate of decrease was 1.46±0.30 ml/min/month in type I diabetic patients with a systolic BP> 160 mmHg versus 0.80±0.42 ml/mm/month with 0.01). In the type II diabetics the respective figures were 1.38±0.40m1/min/month versus 0.78 ± 0.15 ml/min/month (P>0.01). During the observation period the prevalence of coronary heart disease increased from 6 to 50% in type I and from 31 to 87% in type II diabetes. In conclusion, the rate of progression of diabetic nephro pathy during the predialytic phase is similar in type I and type II diabetes; BP adversely affects the rate of progression to the same extent in both groups.

This publication has 0 references indexed in Scilit: